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Serie A Picks & Predictions

Stake - August 11, 2025
News Content

2025/26 Serie A Predictions - Italy Serie A Football Betting Picks & Odds

The Italian Serie A is among the best professional soccer leagues in Europe and home to some of the most famous and historic clubs in the sport. The title race is regularly contested between several top clubs, including the likes of Milan, Inter, Juventus and Napoli. You can bet on all Serie A matches here at Stake Sportsbook, so read on to see our expert picks, predictions and Serie A betting strategies.

What is Serie A?

The Serie A is the top division of professional soccer in Italy. It features 20 clubs from across Italy and is part of the wider soccer pyramid. The league uses a promotion and relegation system with the levels below, meaning any team in the country can reach the Serie A by performing well over multiple seasons and winning promotions. Teams taking part in Serie A also get to participate in the Coppa Italia, and top sides can qualify for European competitions such as the UEFA Champions League.

Serie A History & Past Winners

The Italian Football Championship was founded in 1898. However, disputes over the number of teams taking part led to a split between governing bodies in Italy, and multiple leagues existed for several years. From the 1923-24 season, the winners of the Italian league championship have been granted the honour of wearing the scudetto on their kits the following season.

In 1929, Serie A and Serie B were formed to reorganise Italian soccer into a national meritocracy with 2 main divisions. Although Serie A split from Serie B in 2009 due to an argument over television rights, promotion and relegation have remained in place between the 2 divisions.

There have been a total of 16 winning clubs in the history of the national Italian football championships. Juventus have won the most titles, at 36, while Inter Milan have 20 and AC Milan have 19. Napoli are the current defending champions, having won in 2024/25.

2025/26 Serie A Schedule & Format

Since 2004, Serie A has been contested between 20 clubs, playing in a round-robin format. Each team plays one home and one away game against every other team in the competition. Teams win 3 points for winning a game and 1 point for a draw. A loss awards zero points. These points are used to rank teams on the table, and the club with the most points at the end of the season wins Serie A.

The top 4 teams qualify for the league phase of next season’s Champions League, while the 5th-placed team qualifies for the next season of the UEFA Europa League. The 6th-placed team qualifies for the play-off round of next season’s Conference League.

Here are some key dates for the 2025/26 Serie A season:

  • Opening fixtures: Saturday, August 23 2025

  • Supercoppa Italiana begins: Wednesday, December 17, 2025

  • Final day of the season: Sunday, May 24, 2026

Serie A Picks & Predictions for 2025/26

Although Juventus have the most Serie A titles and dominated the competition between the 2011-12 and 2019-20 seasons, the competition has been far more open in recent seasons, with 3 winners over 5 seasons. Juventus, Inter, Milan and Napoli have all swapped the scudetto between them over the past 6 seasons. This upcoming Serie A could be another close battle between the 4 top teams.

Aside from the title race, the battle to avoid relegation to Serie B is always an exciting one, and there’s also a fight to see which teams can qualify for European competitions. There’s also the Primavera Cup to look forward to, featuring youth teams from the Campionato Primavera,

Who Will Win Serie A?

  1. Napoli - Napoli secured the title by 1 point last season, despite selling one of their key players, Khvicha Kvaratskhelia, in the January transfer window. Under the management of Antonio Conte, they’re a force to be reckoned with, and the signings of Premier League legend Kevin De Bruyne, Sam Beukema and Noa Lang will bolster their squad.

  2. Inter Milan - Inter suffered a terrible defeat in last season’s Champions League final after narrowly losing out on their 21st Serie A title. In addition, head coach Simone Inzaghi left during the summer, hurting their title chances this season. However, they’ve made a few shrewd signings, including Luis Henrique and Peta Sučić, who could make a difference.

  3. Juventus - Juventus may have been a dominant force in Serie A, but they haven’t won a title in 5 seasons now. They’re 3rd favourites to be crowned champions this season, though they’ve already brought in 6 new players, including talented winger Francisco Conceição from Porto. In addition, they have a new coach, Igor Tudor, who was appointed in March.

  4. AC Milan - Milan won their first Serie A title in over 10 years in the 2021-22 season, but remain one of the top challengers. They’re currently 4th favorite in the betting odds and have made some interesting signings, including the free transfer of Luka Modrić from Real Madrid. They’re also appointed former Juventus coach Massimiliano Allegri.

Types of Soccer Bets & How to Bet on Serie A

Betting on Serie A at Stake is really simple. Just follow these steps to get started:

  1. Sign up or log in to your Stake.com account.

  2. Check your current balance and use an accepted payment method and local currency to make a deposit if needed.

  3. You can also bet with crypto at Stake, with a wide range of cryptocurrencies available to use, including BTC, ETH, USDT, EOS, DOGE, LTC, TRX and SOL.

  4. Use Mesh to deposit crypto from a wallet or exchange, or use MoonPay or Swapped.com before storing your coins in the Stake vault.

  5. Search for a Serie A team or use the menu to look for Soccer > Italy > Serie A to see all available live and upcoming matches.

  6. Choose any match to see the full range of soccer betting options.

  7. Select a bet to add it to your bet slip, then enter your Stake and confirm to place.

Learn more details in our ultimate sports betting guide and guide to betting on soccer. There are lots of different ways to bet on Serie A, including the following popular bet types:

  • 1x2

  • Draw No Bet

  • Asian Total

  • Asian Handicap

  • Double Chance

  • 1st Goal

  • Correct Score

  • Both Teams to Score

  • Halftime/Fulltime

  • Outright winner/European qualification/relegation

  • Multi-bet

Live Stream Serie A & Football/Soccer Matches Online

You can watch and bet on every Serie A game as it happens, with a variety of live betting options too. Find out the differences between pre-match and live betting before you begin, and don’t forget to check out our free soccer streams including Serie A games. Once you’re signed in, just look for the live stream icon to watch the full match as it happens.

Serie A Betting Odds, Payouts & Promotions

You should understand the relationship between odds, probability and payouts before you start betting. Make sure you read our guides on how to read betting odds and what the vig is, as these will help you choose the best odds and have more success. You should also check out our sports betting promotions to boost your bankroll and increase the value of your bets.

Soccer & Football Betting Tips, Predictions & Strategies

  1. Research your bets - Don’t just bet blindly, make sure you evaluate all the available data and statistics to back up your predictions. Last season, Serie A matches saw an average of 2.56 goals per game, disproving the idea that it’s a defensive league. Meanwhile, home sides won 40% of games.

  2. Use all available betting markets - Stake covers more than 70 markets on all Serie A matches, giving you more opportunities to find value. Don’t just focus on the 1x2 market; look at Asian totals, player props and more to place successful bets.

  3. Use live betting - Don’t forget about live betting either, which presents an ever-changing number of betting opportunities. Live stats and live streams provide deeper insights into what’s happening, giving you the best chance of placing successful bets.

Stake VIP Club & Responsible Betting

Stake offers a huge variety of betting options on Serie A matches, but that’s not all. When you sign up, you’ll also become a member of the tiered VIP Club, which lets you earn rewards as you place bets and level up your account. Unlock regular rakeback, reload bonuses and even your own VIP host. Find out more details on the VIP FAQ page, and ensure you follow our Stake Smart guidelines to bet responsibly and stay in control.

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